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 New biodegradable microspheres formulated in pressurized CO2
Application to the encapsulation and controlled release of active compounds - Protein loaded PLGA microspheres - Protein loaded CaCO3 microspheres - Impregnated CaCO3 microspheres Propionyl-coA precursors for the treatment of poly-glutamine diseases
Anaplerotic Krebs cycle stimulators as therapeutic targets - Metabolic action - Blood-Brain Barrier permeant Novel Human HER-2/neu antibody fragment
A promising cancer vaccine candidate - Adjuvant therapy in association with standard strategie - Cancer relapse prevention - No immunotolerance problem Bioactive coatings made of polyelectrolyte multilayers
- Different sort of molecules may be included in the film - Small molecules of PM<5000Da and even PM<1000 Da keep their activity - Activity is stable up to 50 layers depth A new generation of polyelectrolyte multilayer film's system
- Multifonctionalized bioactive materials - Tuned activity of the molecules - New properties due to the mixture of polycations and polyanions A new kit for pronostic and therapeutic of colorectal cancers
Better patient classification for high-risk of relapse than TMN histological - A novel approach for the analysis of the intra-tumoral immune infiltrate - Better predictive value than the gold-standard histologic classification - Stratification of patients at high risk of relapse ThyX, a novel thymydilate synthase and related inhibitors
- THYX: dTMP route synthesis of mostly pathogenic bacteria - Mutual exclusion of Thyx and thya in the genome of bacteria and viruses - The human genome does not bear theThyx gene Use of novel flagellin- derived peptides as mucosal adjuvant
- TLR5 agonist - No significant systemic pro-inflammatory effects Polymorphisms in the EPCR gene and thrombotic risk
- EPCR receptor responsible for thrombosis - Differenciation of 3 haplotypes for the EPCR gene - Diagnostic kit for thrombotic risks A novel marker of sensitivity or resistance to anti-tumoral treatment
Theranostic kit for chemotherapy - Vascular Endothelial Cadherin, a body fluids protein - Detection in plasma or serum - Brain solid tumors (glioblastoma) but currently investigating other cancers Broad applications of a crosslinked polyelectrolyte multilayer film
- An infinite variety of architectures - A long term use of this film due to the important stability - Neither allergic reaction nor excessive inflammatory response Anti-Restenosis by MRP4 gene inhibition
- siRNA proof of concept in vivo - drugable membrane protein Spatiotemporal cartography Software by multiple-target tracing method probe
High Throughput screening software for multiple targets - Tracing over 1000 simulataneous targets - In heterogeneous media with high noise - Dynamic tracing as well (instantanous) Method for quantifyingVEGF121/VEGF 165 isoforms in a biological sample
Prognosis of survival in solid cancer and AML - Linked to angiogenesis - Poor and bad prognosis of event-free and overall survival - Extremely sensitive detection of isoform A method for predicting the responsiveness to anti-TNFa antibody treatment
IL15 and sIL15Ra implicated in the response to treatment in Crohn's disease - Inflammatory disease and Biomarker in Crohn's disease - Response to Infliximab in Crohn's disease - A specific modulation of IL15 and sIL15Ra An in-vitro method for expanding monocytes
- Application #1: cell models for research and screening - Application #2: cell-based biotherapies - In-vitro method based on inactivation of MafB and c-Maf genes in monocytes Artemis,a gene implied in DNA reparation and VDJ recombination
- Gene therapy for the SCID: severe combined immunodeficiency. - Radiosensible SCID observed in this study. - Identification of the implication of a gene in SCID. the NPHS2 gene implicated in steroid-resistant nephrotic syndrome
- NPHS2: identified and mapped to chromosom 1 - A hot spot of mutation - Prediction of reccurence after transplant human Skin substitutes from Human Pluripotent Stem Cell
1st truly established skin substitutes worldwide - Application in screening and toxicology - Provide all possible phenotypes - Skin lines with reproductible results A new treatment for glomerulonephritis
- EFGR antagonist or inhibitor of EFGR for treatment - CD9 implied in the EGFR activation - Enlargement of treatment to other alloimune diseases Prediction of the responsiveness to a treatment for Multiple sclerosis
- The first useful biomarker for multiple sclerosis diagnostic - Identification of a group receptive to IFN-β treatment - Reduction of the public health costs Fluorescent Nano diamonds and its method of production
Use as a labeling marker/tool for research, in-vitro diagnostic - Consistent and permanent fluorescence - Replicable and industrial process, classical surface chemistry - Can bind to any biologicals (DNA, RNA, protein, etc) Methods for the treatment,the prognostic and the detection of breast cancer
Early diagnosis-differentiate at stage 0 between calcification and tumor - Diagnostic imaging of breast cancer. Relapse prognosis. - Alternative to MRI-based mammography (false positive and higher cost) - Radiotherapy and therapeutic application A strategy to generate new compound conformations with enhanced efficacy
The concept : sublimation under vaccum followed by solid deposition - Sublimation followed by deposition alters compound conformation - Compound conformation of the deposit gains in therapeutic efficacy - Gain in efficacy reflects gain in bioavailability or biological activity CD31-derived fragment for the treatment of atherosclerosis
A new therapeutic window through immunoregulation - Diagnosis + Therapeutic proof of concept on the target - Minimal peptidic sequence identified - Significant clinical evidence CNF1 and related Rho GTPases activators as adjuvant for mucosal vaccination
- Product: CNF1 bacterial toxin as adjuvant - Application: mucosal vaccination, proof of concept in nasal and oral models - Novel action mechanism: transient and reversible activation of Rho-GTPases Identification of genetic markers associated to cancer of pancreas
CNV-based biomarker in sporadic pancreatic cancer - Diagnostic of a predisposition to the pancreatic cancer - Inhibitor of the genes proteins activities for the treatment - Identification of a CNV signature. New polypeptides in cancer therapy
- HSP70: a new therapeutic target - Smaller inhibitors for an easier use - Peptidic aptameres as therapeutic agents Novel antibacterials for treating latent tuberculosis
Novel original target from dormant tuberculosis bacillus (TB) - Product: carbapenems - Target: L,D-transpeptidase, expressed in dormant tuberculosis bacillus (TB) - Indication: latent tuberculosis The role of a phosphotase PTPL1 as survival prognostic in breast cancer
- Biomarker of breast and ovaries cancers: PTPL1 - Development of an immunocytochemistry dosage - Diagnostic and prognostic tests Novel imaging agents for fibrosis (lung, heart, liver)
- Fibrosis diagnosis - Lysil Oxidase Enzyme binders as imaging agents - Acute treatment should be provided Prognostic of breast cancer development into local metastasis (bone, lung)
- Molecular signatures of osseous and lung metastasis - Experiments on human samples - Targeted therapy Inhibitor of STIM1 for the treatment of cardiovascular disorders
- STIM1: a protein that activates NFAT - NFAT induces cells proliferation and cardiac hypertrophy - RNA interference to inhibit STIM1 Antagonists and agonists mutants of humans IL-15
Control of the IL-15 affinity for its receptor IL-15α - Interleukin-15 induces NK and T cell proliferation and activation - Development of new IL-15 mutants - Prevention and treatment of human pathology by IL-15 activity modulation Interleukin-15 receptor: a biomarker of survival for head and neck cancers
- Prediction of survival in HNSCC patients - Increase level of soluble IL-15Rα in HNSCC patients - soluble α chain: biomarker of these cancers Microsensor of arterial pressure
- Non-invasive pulse wave velocity measurement - High fidelity pressure microsensor - Vascular alteration prognostic Method for predicting therapeutics responsiveness to TNF-a blocking agents
Inflammation and Biomarker in Rheumatoid Arthritis (RA) - Polymorphisms of the TNF gene : identification of a single TNF haplotype - A single TNF haplotype influences the response of Adalimumab in RA - Large pharmacogenetic study Methods of classification and prognosis of hepatocellular carcinoma
- HCC is an heterogeneous group of tumours - A reliable classification for adapted treatments - 6 distinct subgroups from genotype-phenotype correlation Biomarker for liver lesions diagnosis of obese patients
- Diagnosis devoid from risk - Free hemoglobin as biomarker - Studies on both morbid and non-morbid obesity Early diagnosis of prostate cancer using a protein receptor
Imaging, In vitro diagnostic, radiotherapy and immunotherapy - Protein Receptor expressed in vascular cells for prognosis - Expressed in prostate tumors and other solid cancers - Imaging application, Development of tumor blood test Methods for the prognosis or for the diagnosis of a thyroid disease
- Molecular classification - Marker genes for thyroid disease diagnosis - Precise identification of all thyroid diseases A gene-based classifier for prognosis in multiple myeloma
Prognosis of disease outcome for treatment selection - More acurate patient stratification than current ISS standard - Especially for high risk patients - Blood sample Highly Sensitive Prion Detection Technology
- Chemical-based amplification of the pathological prion protein - Applicable to human and animal samples Use of HB-19 pseudo-peptide to inhibit infection by Francisella tularensis
- Product #1: HB-19 and related compounds, specific ligands of nucleolin - Product #2: EF-Tu of F. Tularensis as a vaccine - Novel targets: EF-Tu / cell surface nucleolin interaction Novel diagnostic agent of the liver function reserve (LFR)
Radiopharmaceuticals with simplified preparation - Binds specifically to hepatocytes - Safe and cost efficient (based on human albumin) - Scintigraphic agent (technetium) Fusion proteins for optimal antigen presentation in vaccine strategy
- Optimized fusion protein for efficient antigen processing - Specific monoclonal antibody targeting dendritic cells A novel therapeutic vaccine approach for resistant pathogens
- Product: vaccine (preventive and therapeutic) - Novel therapeutic vaccination method - Novel action mechanism: CCL3 dépendant Uridine derivatives as antivirals against a flaviviridae, especially HCV
- Product: inhibitors of HCV replication Prognosis and diagnosis of agressiveness of non small cell lung cancer
Based on a protein and its corresponding receptor - Diagnostic imaging of non small cell lung (potentially colon, breast) cance - Monitoring of cancer Severity and its progression - In-vitro diagnostic and radiotherapy New Gossypol derivatives promotes apoptosis in cancer cells
- Chemical familly already in clinical development - Specific inhibition of the bcl2 family - Chemical Therapy orally available
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